Inheritance

Autosomal tests have become popular in the last 5 years for identifying connections between people who have inherited the same same DNA from ancestors, also known as relatives. This autosomal testing provides them with an unprecedented means for understanding how genes are passed down. Understanding genetics can have positive effects in advancing both genealogical records and personal health-related decisions. Below are screen captures of one of the 20 or so user-friendly interfaces called Family Inheritance that members who have taken advantage of the Giants’ kits are accessing for analyzing their own chromosomes. Members can use this to determine through which parent or grandparent they are related to an individual and make genealogical breakthroughs by collaborating with thousands of other users and including hundreds of newly discovered cousins.
For several of the genome comparisons from our 23andme analyses, highlighted in red are the genes regulating immune system compatibility. Potentially, one could also use such information to identify siblings, or members of the community/world with whom one might be compatible with respect to organ/stem cell donation. Currently, with only about a 1 in 5 chance of a perfect match between siblings, it is difficult for many parents to justify the expenses of cord blood banking for each child. If one were able to identify empirically that a substantial number of immunological matches exist between members of our closely related community and also members of the Norwegian towns from which most of our genetic material originates, then a smaller pool of existing cord blood cells could be expanded and used for a larger number of individuals. Identifying whether matches existed beyond one’s siblings would significantly increase the pool of compatibility for stem cells and organs and make stem cell banking much more practical.
John & his mother
John & his father
John & his hypothetical identical twin
John & his brother David
John & sister Jill
John’s brother David & sister Jill
John's dad Lew and John's possible 4th cousin
John’s daughter Elyse and John’s possible 4th cousin

2 Replies to “Inheritance”

  1. Since John had a complete sequence done, were chromosomal chains separated so each could be individually sequenced and analytically define the maternal and paternal contribution or was a blended sequence obtained so their contribution was defined from the parental sequences.
    Since you have parents and siblings sequences and possibly children sequences, perhaps a diagram with pairs of sequences might be more informative with colors following the assortment of maternal and paternal sequences. It would better reflect inheritance and allow one to see the passing of sequences through the generations.
    A great project – congratulations!

  2. Apparently in the USA where I was born, my great Aunt and Uncle started population and making a town out of Portland Oregan. Also years ago the computer said I had an inhertance is this true.

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